Case Studies

Hyperbaric oxygen therapy for treatment of post-concussion syndrome and post traumatic stress disorder

A 25-year-old male military veteran presented with diagnoses of post concussion syndrome and post traumatic stress disorder three years after loss of consciousness from an explosion in combat. The patient underwent single photon emission computed tomography brain blood flow imaging before and after a block of thirty-nine 1.5 atmospheres absolute hyperbaric oxygen treatments. The patient experienced a permanent marked improvement in his post-concussive symptoms, physical exam findings, and brain blood flow. In addition, he experienced a complete resolution of post-traumatic stress disorder symptoms. After treatment he became and has remained employed for eight consecutive months. This case suggests a novel treatment for the combined diagnoses of blast-induced post-concussion syndrome and post-traumatic stress disorder.

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Note relative improvement in brain blood flow to bilateral focal frontal and temporal defects and overall normalization of blood flow to a more homogeneous pattern.

Hyperbaric oxygen therapy (1.5 ATA) in treating sports related TBI/CTE: two case reports

Despite adequate evidence, including randomized controlled trials; hyperbaric oxygen is not yet recognized as efficacious for treating various forms of brain injury, specifically traumatic brain injury. Political-economic issues have kept this benign therapy from being widely adopted despite the lack of viable alternatives. Two football players with TBI/CTE are herewith shown to benefit from being treated with hyperbaric oxygen as documented by neurocognitive examinations and functional brain imaging, in one case treatment commenced decades after the brain injury. Perhaps the interest in HBOT by those participating in high-risk sports will help expand this orphan therapy into mainstream medicine.

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Pre and post HBOT SPECT imaging showing overall improved blood flow in the post HBOT scan (per Daniel Amen, MD).

Hyperbaric Oxygen Therapy and SPECT Brain Imaging in the Treatment of Chronic Brain Injury

  • Refined low-pressure Hyperbaric Oxygen Therapy (HBOT) protocols for neurological injuries.
  • Presentation includes selective sampling of nearly 400 chronic brain injuries over the past 12 years.
  • After demonstrating effectiveness in humans, a 1996 and 2001 animal study demonstrated the first ever improvement in chronic brain injury
  • World-wide experience has demonstrated the generic rehabilitative potential of low pressure HBOT in chronic brain and neurological injury.
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Acute & Chronic Treatment of Traumatic Brain Injury and Coma 19 y. male

The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study

Recently, hyperbaric oxygen therapy (HBOT) has increased in popularity as a treatment for autism. Numerous studies document oxidative stress and inflammation in individuals with autism; both of these conditions have demonstrated improvement with HBOT, along with enhancement of neurological function and cognitive performance. In this study, children with autism were treated with HBOT at atmospheric pressures and oxygen concentrations in current use for this condition. Changes in markers of oxidative stress and inflammation were measured. The children were evaluated to determine clinical effects and safety.

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Changes in mean CRP before and after hyperbaric therapy at both 1.3 atm and 1.5 atm. P-values and blood levels are listed above the bar graphs.